We can all store a certain amount of fat safely before fat starts accumulating in places like our liver and pancreas and causing problems.
The point at which you are unable to store fat safely is termed your personal fat threshold. This is individual and is largely influenced by genetics. Fat storage above this point contributes to the progression of type 2 diabetes.
The twin cycle theory proposes that fat accumulation in the liver and pancreas are key to the development of type 2 diabetes.
Fat accumulation in the pancreas impairs insulin response to ingested food.
Fat accumulation in the liver increases resistance to insulin mediated suppression of glucose production. Normally when insulin is present this is a sign that there is enough glucose already and our body’s own insulin production is turned off. However, if the liver becomes insulin resistant it can’t sense the presence of insulin and thus continues to produce glucose adding to already elevated blood glucose levels.
The personal fat threshold theory also explains why some people are metabolically healthy at a certain body fat % while others develop type 2 diabetes.